Friday , November 27 2020

Find a possible link between the add-on and the Parkinson's – 11/05/2018



There are links between Parkinson's and gastrointestinal tract. But now a group of scientists have discovered a link with the add-on that it adds new songs to investigate the origin of this disorder.

According to a study published today in the journal Science Translational Medicine, people who had a supplement removed from young people had between 19% and 25% less risk of developing Parkinson's population.

"Our results point to the addition as a place of origin for Parkinson's and provide a way to design new treatment strategies to use the role of gastrointestinal tract in the development of the disease, "said lead author Viviane Labrie of the Van Andel Research Institute in Michigan, USA.

Why? A look at the tissue of the extensible additive shows that this small organ, often considered useless, seems to be depositing abnormal protein (alpha-synuclein abnormally switched) that, if it comes to the brain, it becomes the central feature of Parkinson's disease.

Great surprise, according to the results of work, is that many people can have concentrations of this troubling protein in their additives: young and older, people with healthy brains and with Parkinson's.

But do not rush the surgeon.

"We do not say it goes and is subject to apendectomy," said a neuroscientist and geneticist led by a team of researchers who analyzed data from two major epidemiological studies, one of 1.6 million people and another 91 million. .

After all, many people without organs eventually develop Parkinson's and others who have protein never get sick, the article writes.

Reducing the risk became apparent when the add-on and alpha-synucleulin contained eliminated at an early stage of life, years before the onset of the disease, indicating that the organ can participate in its formation. However, the elimination after the disease process did not affect his progress.

In the general population, people who had an appendectomy were 19% less likely to develop Parkinson's disease, which increased in people living in rural areas, with a 25% reduction in the risk of developing the disease. On the contrary, interventions did not have obvious benefits in people with a disease associated with genetic mutations transmitted by their families, which makes up less than 10% of cases.

The efforts of the scientific community are focused on understanding the origin of this disorder, so it can be treated early, as patients are now coming to the office when motor symptoms, such as tremor or stiffness, are a sign that the disease has already progressed.

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Doctors and patients have known for some time that there is a link between the gastrointestinal tract and Parkinson's disease. Other problems of the tract also occur They are common in people who then begin to experience tremor and other movement problems that lead to diagnosis of the disease.

A recent study will spur new research in order to try to find new clues to determine why and who are really at risk.

"It's a piece of puzzle, the basic term"Dr. Allison Villis, a Parkinson specialist at the University of Pennsylvania, who was not involved in new studies, but says her patients regularly ask about gastrointestinal connections.

James Beck, the chief scientist of Parkinson's Disease Foundation, who was not a part of the study, also said that "There are many promising connections".

He noted that despite their reputation, supplements play a role in immunity that can affect inflammation. The type of bacteria living in the additive may also affect Parkinson's disease.

(Source: AP / LAURAN NEERGAARD-EFE)


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