Friday , January 27 2023

France: researchers have managed to eliminate HIV-infected cells


Scientists at the Pasteur Institute (France) managed to destroy HIV-infected cells after identifying the properties of CD4 T lymphocytes that are predominantly infected with the virus. The metabolic activity of these lymphocytes is what enables the spread of HIV, but researchers have managed to inhibit them.

The antiretroviral treatment used today is designed to block HIV infection but can not eliminate the virus from the body. The virus remains in reservoirs, immune cells of CD4 T lymphocytes, the main targets of HIV. However, the virus does not infect all types of CD4 cells and for now the reason for this is unknown.

In this study published in the journal & Lt; / RTI & gt; Cell metabolism, Scientists from the HIV, inflammation and persistence unit at the Pasteur Institute and their colleagues have identified the characteristics of various subpopulations of CD4 that are associated with HIV infection.

The more they differentiate or experience CD4 cells, the more they need to produce energy to perform their function. Experiments have shown that the metabolic activity of the cell, and in particular its glucose consumption, plays a key role in the vulnerability to HIV infection.

The virus is mainly directed to cells with high metabolic activity. In order to multiply, it captures the energy and products provided by the cell.

This request is a weakness for the virus and can be exploited to combat infected cells, according to the people in charge of the study.

Scientists have succeeded in blocking ec vivo infection due to inhibitors of metabolic activity already studied in cancer research.

"We noticed ec vivo that thanks to certain metabolic inhibitors, the virus no longer can infect cells, and amplification stops in the reservoirs of patients receiving antiretroviral treatment," they explain in their article.

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