Tuesday , May 30 2023

UC researchers released $ 3.4 million from NIH to study the gastrointestinal lymphatic system


A team of researchers at the University of Cincinnati School of Medicine received $ 3.4 million from the National Institute of Health (NIH) to study the role of the gastrointestinal (GI) lymphatic system in absorbing nutrients of nutrients and transporting signaling molecules.

The lymphatic system is a network of vascular channels that allow the return of a lymphatic colorless liquid that contains a white blood cell that undermines the tissues and leads through the lymphatic system to the bloodstream, back to the circulatory system. In the gastrointestinal tract, lymph circulation has the additional function of transporting triglycerides of rich chylimicrons, different hormones and signaling molecules secreted by gastrointestinal tract cells.

"Compared with other systems, heart or respiratory, we currently have a relatively poor understanding of the physiological significance of the GI lymphatic system necessary for the normal functioning of GI tract and overall metabolic health," said researcher Patrick Tso, PhD, professor and Marie M. Emeri Chair of Pathology at the Department of Pathology and Laboratory Medicine at the Faculty of Medicine and Director of the Cincinnati Mouse Metabolic Phototypes Center. Prof. dr. Ivonne Ulrich-Lai, associate professor of pharmacology and system physiology, and Dr. Min Liu, a professor of pathology and laboratory medicine, are the main investigators of the study.

GI lymphatic system, said Tso, may be a critical area of ​​study relevant to diabetes.

For example, he says that when patients undergo bariatric surgery, in most cases, their diabetes turns quickly, before they begin to lose weight. Ulrich-Lai, Liu, and Tso believe that a disorder of lymphatic circulation can be involved in this very interesting clinical finding.

In this study, the researchers will create a similar disorder of the lymphatic system drainage in the animal model to assess its impact on metabolic health.

"We hope to see a mechanism that involves the change of diabetes by bariatric surgery," Tso says.

TSO joined the Department of Pathology and Laboratory Medicine at the University of Medicine University of the United States in 1996 as a professor of pathology and an engagement at the Department of Physiology. Career Tsoa includes positions as Assistant Director of the Research Center for Obesity; director of the Center for metabolic phenotypicism Cincinnati Mouse and director of the Lipid Research Center. In 2010 he received the medal Daniel Drake, the highest honor awarded to the Faculty of Medicine.

A five-year $ 3.4 million grant comes from the National Institute for Diabetes and Nutrition and Nutritional Diseases (NIDDK) (1RO1DK119135-01).

Investigators do not cite any conflicts of interest.

Provides the University of Cincinnati Academic Health Center

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