A group of researchers from the French Institute Pasteur has made a new step in the fight against AIDS (HIV) virus that revealed the way to eliminate infected cells, according to a study published today by the Metabolism Cell.
This finding, announced by the Pasteur Institute, could revolutionize the treatment of HIV, as so far, patients have to take antiretroviral drugs that do not kill the immune cell reservoirs (latent viruses) found in immune cells, "Our job is to we identify infected cells in order to better focus on them in order to eliminate them from the body, "said study coordinator Spanish Asier Saez-Cirion of the Pasteur Institute in a statement broadcast on RTL radio.
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The team of researchers could identify the properties of CD4 T lymphocytes, immune cells that HIV activates and uses to produce copies of themselves. The treatments that exist – antiretroviral – prevent HIV from doing it and multiplying, but do not cure or interrupt the virus, but leave it in a calm state.
Now researchers have found that the virus primarily infects cells with strong metabolic activity – such as CD4-, in which glucose consumption plays a dominant role.
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Understanding this mechanism will open the door to eliminate infected cells, experts say. What the researchers have achieved is blocking the infection due to inhibitors of metabolic activity that has already been investigated against cancer in rabbits ek vivo, that is, performed in or on the biological tissues of the organism in the artificial environment.
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The researchers said that the finding was the first promising step, although they clarified that it was still necessary for this technique to be applied in patients.