Tuesday , March 28 2023

Detection of a serious link between the additive and Parkinson's disease: a big step forward


Parkinson's disease is affected by the additive. These are summaries and hypotheses supported by neuroscientists from around the world who initiated a large study of nearly 1.7 million patients. Published in the journal Science Translation Medicine, the study shows that patients who have removed the supplement have up to 25% less chances of not being affected by Parkinson's disease.

Obvious connections

Parkinson's disease, named after James Parkinson and described in 1817, the second most common neurodegenerative disorder afterwards Alzheimer's disease. Also known as the disease of aging, it begins about 45 years and can be reported in the next 30 years. It is a degenerative chronic neurological disease, that is, a progressive brain loss that leads to the lack of dopamine in certain brain structures. This affects the central nervous system (responsible for progressive disorders: slow movements, tremors, rigidity and cognitive disorders). His causes remain a little familiar, although there is considerable evidence that the bowel is partly responsible for this.

Indeed, today we know that in the intestines Parkinson's disease develops using a nerve to return to the brain. A fact that is not surprising, because one of the first symptoms of the disease is constipation. The researchers also noted that the protein, alpha-synuclein (a protein that was just associated with the disease) was in the form of abnormal lumps in the gastrointestinal tract. Viviane Labrie, the leading author of the study, explains that " although his reputation is generally "useless", the supplement actually plays a major role in our immune system in regulating the composition of our intestinal bacteria, and now, as our work shows, at the onset of Parkinson's disease"Let's understand here that the alpha-synuclein protein accumulates in the intestines after an immune reaction to toxins and bacteria.

However, this is a difficult explanation for maintenance as the primary cause of Parkinson's disease. As a kidney disease, it takes several years to discover that dopamine cells degrade to the extent that the body experiences tremor or rigidity of the muscle. However, researchers believe that brain cell damage is associated with how alpha-synuclein is blamed and agglomerated by some people. In addition, it can be noted that over the course of a decade, the accumulation of this protein is increasingly significant, which leads to alarming interactions between the brain and the intestine. Strong evidence certainly, but there is a fact that slow progress of the disease is more desirable in people who are considered at risk. This makes difficult study results and interpreters for people who at first do not pose a risk.

© ioutube / FUTUREMAG – ARTE

How to better understand the causes?

Recently, this research was conducted by neuroscientists around the world who supported two hypotheses about the possible causes of Parkinson's disease. For this, they linked the details of PPMI (Parkinson's progressive marker initiatives); It is an observational clinical study that comprehensively evaluates important cohorts of interest using advanced imaging, biological sampling techniques, and clinical and behavioral assessments, to identify biomarkers of progression of Parkinson's disease. And records of the Swedish National Register of Patients in order to seek possible connections between neurodegenerative diseases and apendectomy.

A large-scale study focusing on monitoring nearly 1.7 million people shows that the difference is almost 20% less likely to be more prone to Parkinson's disease among patients with no additive and those with intact intake. Better yet, the researchers compared the comparison even with the places where patients lived between urban and rural areas, and noted that the difference was 25% less fortunate for people who no longer had the Supplement.

The study does not show in any way that the removal of the additive will make you immune to illness, but provides additional insights into the causes of Parkinson's disease. according to Vanessa Fleuri, a neurologist at University Hospital in Geneva, "This study supports two hypotheses: Parkinson's disease begins early in the digestive tract, and environmental factors, such as exposure to pesticides, play a role in the emergence of pathology into genetically predisposed individuals."

Source link