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Cranberries and antibiotics join together to defeat bacteria

Global spread of antibiotic resistance undermines decades of advancement in the fight against bacterial infections. Due to excessive use of antibiotics in medicine and agriculture, we are getting closer point (Graphic) from the rocking chair (Flip-flop or flip-flop is a logically integrated circuit with an output and one or more inputs, the output can be at logic level 0 or 1. Changes …) that would put us back in a pre-antibiotic era where less infections could once again become life-threatening. Therefore, it is essential to make up for reducing the effectiveness of antibiotics by improving the effect of currently available antibiotics.

little fruit (In the botanic, the fetus is a plant organ that protects the seed. Characteristic of Angiosperme, the flower flourishes with the transformation of the pistol.) they were looking for him taste (For the ability to rate beautiful things, see Ukus (aesthetics)) acidified and its antioxidants cranberry (Cranberry, North American North American cranberry or athlete (in Quebec) or named after its English name, cranberry, is a growing bush … also helps fight bacteria, according to a new study published in the journal Advanced Science. By treating them with molecules extracted from cranberries, pathogenic bacteria become susceptible to lower doses of antibiotics. Moreover, they do not develop resistance to these antibiotics according to the discovery of researchers fromuniversity (University is a higher education institution whose goal is the production of knowledge (research), its preservation and transfer (higher education) …. McGill iinstitut (The Institute is a permanent organization created for a specific purpose, usually a research institution, for example a Perimeter …) national scientific research (Scientific research refers primarily to all the actions that are being undertaken in order to produce and develop scientific knowledge.) Metonymic extension, scientific research also applies to … (INRS) to montreal (Montreal is also the administrative region and the metropolis of Kuebeca[2]. This great Canadian agglomeration is the main center of commerce, industry, culture, finance and ….

While popular wisdom proposes to drink cranberry juice to treat urinary tract infections, the researchers wanted to learn more about the virtues of this fruit by treating various bacteria with their extract. Bacteria selected for research are responsible for infections such as urinary tract infections, lung inflammation, and gastroenteritis (Proteus mirabilis, Pseudomonas aeruginosa i Escherichia coli).

"Usually, when we treat a bacteria (Bacteria) are prokaryotic single-celled organisms, characterized by a lack of nuclei and organelles. Most bacteria have a cell wall of carbohydrates, peptidoglycan, … with a antibiotic (Antibiotic (from Greek anti: "against", and bios: "life") is a molecule that destroys or blocks …) during a certain one time (Time is a concept that a human being has developed to understand the changes in the world.) in the laboratory, it certainly develops resistance, "explains Nathalie Tufenkji, a professor of chemical engineering at McGill University and the lead author of the study." Bacteria were treated with antibiotics and antibiotics. cranberries, and resistance did not appear. This result has surprised us much and we see it as an important opportunity. "

Analyzes have found that cranberry extract makes bacteria more susceptible to antibiotics by acting on two fronts. First, the bacterial wall allows antibiotics to enter and, second, the bacterial mechanisms that evacuate the antibiotic are slow. medicine (Lek is a substance or composition that has medicinal, preventive or administrative properties to establish …) therefore it is better to enter the bacterium and get out of it with greater difficulties, which explains why their effect is effective at a lower dose.

"These are very exciting results," says Eric Deziel, microbiologist and professor at INRS. "This one activity (The term activity can relate to the profession.) It comes from molecules called proantocyanidins. There are several different and it is possible that they act together (In the theory of sets, the set intuitively denotes a set of objects (elements of a set), …) to achieve this result. We'll need more search (Scientific research primarily refers to all the activities that are being undertaken in order to produce and develop scientific knowledge, and by expanding metonymy, scientific research refers to …) to find out who are most active in synergy with antibiotics. "

After confirming the activity of cranberry molecules on bacteria in culture (UNESCO's definition of culture is as follows [1] 🙂, the researchers checked whether the action remained on the model animal (An animal (from the Latin animus, spirit or vital principle) is, according to the classical classification, a heterotrophic living being, that is, it is fed to organic substances.) preliminary, insects (Insects is a magazine for ecology and entomology in French for a wide audience of amateurs and naturalists, produced by the Insect Office and their …) infected. As the synergistic effect between the extract and the antibiotic is also observed, the experiments will continue to clearly identify the active molecules.

If the results are confirmed in animals, some antibiotics for which there is strong resistance can find their importance by increasing their potential through molecules derived from cranberry extract.

"We look forward to continuing this research," says Nathalie Tufenkji. "Our hope is to reduce the required doses of antibiotics medicine (Medicine (from Latin medicine, "who cures") is science and practice (art) that studies the organization of the human body (anatomy), its normal functioning (physiology), …) to fight against antibiotic resistance. "

About this study

Article "Proanthocyanidine affects internal resistance mechanisms to antibiotics of gram-negative bacteria" (Adv Sci 2019, 1802333. DOI: 10.1002 / advs.201802333) reports on the work of Vimal B. Maisuria, peace (Mira can show 🙂 Okshevsky, Eric Deziel and Nathalie Tufenkji. It is published in Advanced Science, a revised journal and can be freely accessed.

This research has received financial support from the Canadian Research Council for Natural Sciences and Engineering, the Canadian Research Chair and Chair for Ocean Research. spray (The Sprai is the name of a boat used by Joshua Slocum to complete his solo tour around the globe that celebrated him.) McGill University has filed a patent application for the use of phenolic compounds derived from cranberries as synergistic antibiotics against pathogenic bacteria in which Nathalie Tufenkji and Vimal B. Maisuria is listed as inventors.

https: //onlinelibrari.vilei.com/doi/10.1002/advs.201802333

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