Saturday , November 28 2020

gene modification can be more effective than the vaccine



The researchers would find an alternative to the influenza vaccine. Their study, potentially revolutionary and published in the journal science, shows that a gene that would enter the genetic capital of the nasal cells would allow them to cure an antibody capable of fighting with 59 types of influenza virus from 60 subjects.

The vaccine is never 100% effective

As the virus virus mutates constantly and randomly, the vaccine is never effective: from year to year, viruses change sufficiently to avoid the immune response that has been developed against the virus. The previous year: they can infect people who already have flu and the vaccine must be repeated every year.

In particular, even if it adapts to different parameters each year (the virus circulates in the previous year and in different regions of the world, probabilistic analysis …) and if it is directed against several types, the influenza vaccine can only partially cover viruses that will actually occur . First of all, if, as in the course of the 2017-1017 epidemic, two viruses circulate: the vaccine was effective compared to the first (A (H1N1) pdm09 virus), but not to the other (Iamagata BB virus) which had time for development due to the length of the epidemic.

In the end and for all these reasons, the flu vaccine can not be 100% effective, and this is partly why many Frenchmen avoid it.

Other strategies being tested

Of course, the universal vaccine graal is focused on a more stable and universal component of the virus, but we are still far from it. On the other hand, researchers have found that some people naturally produce antibodies that can fight many types of influenza viruses.

They then created a gene that is capable of generating the production of these antibodies, and then it is injected into the mouse nose cells with a harmless vector virus ("transfection"). The mouse nodules that received the transplantation of this gene were then able to make this famous antibody. Sixty strains of influenza virus were then tested by ejaculation to these animals, and only one fear of 60 was not controlled by antibodies … but 59 was.

Multidomain Antibody

"The MD3606 multidomic antibody protects mice from influenza A and B infections when administered intravenously," researchers conclude. "Our results show that multidominal antibodies have increased cross-reactivity and viral activity and can be an effective strategy to prevent infections with flu and other highly variable pathogens," they add.

It's interesting, but it's on the mouse and this should not stop you from vaccination this year against the flu. Not 100% effective, influenza vaccine protects against the most severe infections: last year, a vast majority

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