Thursday , August 11 2022

Stress hormones may exacerbate breast cancer, including those derived from anti-inflammatory drugs



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Stress is a risk factor for many diseases and is present everyday in our life, especially pathogenic when it occurs chronically. However, some anti-inflammatory drugs can promote their increase in the body and that Hormones of stress can aggravate breast cancer according to a recent study published in the journal Nature.

More hormone stress, more metastases

The researchers analyzed the data derived from breast cancer models originating from patients on mice, observing a increased glucocorticoid receptor activity in those who had metastasis or tumor heterogeneity within the patient (i.e., differences within the tumor or between tumors in the same patient).

This last condition that compels it to be treated with different tumors heavy treatment to a greater extent than metastasis, which is given by the colonization of cancer cells within the body.

So it's noticed glucocorticoid receptor is activated by an increase in stress hormonewhich can naturally occur when dealing with a stressful situation or when glucocorticoids are introduced which are synthetic derivatives of cortisol.

The glucocorticoids are immunosuppressive and antiinflammatory and are usually given to patients with cancer, as well as those with other pathologies, therefore the study is a call to wake Avoid excessive use because her entry could aggravate breast cancer by encouraging metastases and tumor heterogeneity.

Among the most common glucocorticoids is prednisone, hydrocortisone, betamethasone, Beclomethasone and the like.

Image | Pikabai

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